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WELCOME TO BIOMATERIALS & MECHANOTRANSDUCTION LAB

Our group aims to regulate cell function and fate via applying biomaterial cues (chemical and topographical micro/nano substrates, surface energy tuning) and mechanical signals (fluid shear, mechanical stretch, impulsive pressurization) and through co-regulation from biomaterial-mechanical cues.  Further, by integrating molecular manipulation (RNA interference or overexpression) of key signaling molecules, including FAK, ROCK, Nesprin, Cadherin, and NF-κB, we aim to reveal the role of focal adhesion, cytoskeletal tension, nucleoskeleton-cytoskeleton linkage, cell-cell junction, and immune response in cells sensing and responding to biomaterial-mechanical loading environments.  Our investigation on the crosstalk between engineered extracellular milieus and molecular signaling cascades in cell-biomaterial interaction and mechanotransduction will provide high impact mechanistic data for biomaterials science, mechanobiology, and regenerative medicine.  See more RESEARCH.

Dr. Lim received a NE DHHS Stem Cell Research Project grant titled "Role of YAP Mechanotransduction in MSC Fate Decision (PI: Lim)."  See more NEWS.

For more information, please contact Dr. Jung Yul Lim (jlim4@unl.edu, 402-472-2480, W317.3 Nebraska Hall) or the lab (402-472-2485, 129 Scott Engineering Center).

Link to:
Dept. of Mechanical and Materials Engineering; Faculty Page
College of Engineering
University of Nebraska-Lincoln
UNMC Regenerative Medicine Program; Faculty Page