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WELCOME TO BIOMATERIALS & MECHANOTRANSDUCTION LAB

Our group aims to regulate cell function and fate via applying biomaterial cues (chemical and topographical micro/nano substrates, surface energy tuning) and mechanical signals (fluid shear, mechanical stretch, impulsive pressurization) and through co-regulation from biomaterial-mechanical cues.  Further, by integrating molecular manipulation (RNA interference or overexpression) of key signaling molecules, including FAK, ROCK, Nesprin, Cadherin, and NF-κB, we aim to reveal the role of focal adhesion, cytoskeletal tension, nucleoskeleton-cytoskeleton linkage, cell-cell junction, and immune response in cells sensing and responding to biomaterial-mechanical loading environments.  Our investigation on the crosstalk between engineered extracellular milieus and molecular signaling cascades in cell-biomaterial interaction and mechanotransduction will provide high impact mechanistic data for biomaterials science, mechanobiology, and regenerative medicine.  See more RESEARCH.

Dr. Lim received NE DHHS Stem Cell Research Project grant titled "Role of YAP Mechanotransduction in MSC Fate Decision (PI: Lim)."  See more NEWS.

For more information, please contact Dr. Jung Yul Lim (jlim4@unl.edu, 402-472-2480, W317.3 Nebraska Hall) or the lab (402-472-2485, 129 Scott Engineering Center).

Link to:
Dept. of Mechanical and Materials Engineering; Faculty Page
College of Engineering
University of Nebraska-Lincoln
UNMC Regenerative Medicine Program; Faculty Page